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pentobarbital will reduce the level or result of methadone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will lower the level or impact of loratadine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital decreases levels of toremifene by affecting hepatic/intestinal enz